Cytochrome modulation decreases the risk of cataract: Is the basic hypothesis flawless?

reductase is present at other sites like kidney, placenta, and seminal vesicles,[3] its presence at these places cannot be responsible for cataract formation. Moreover, the drugs used in this experiment, i.e. pioglitazone and diltiazem, are bound to plasma proteins to an extent of 99% and 80%, respectively.[4] So, it is doubtful if they will accumulate in eye in sufficient quantities to have their effect. 5. The authors have used pioglitazone as an enzyme inducer but doubts have already been raised on its potential to induce CYP3A4.[5,6] 6. Authors have used galactose-rich diet to induce cataract although it has been argued that galactose fed rats are not a good model of diabetes and the subsequent induction of cataract.[7] It has also been pointed out that the use of galactose fed animal models leads to subsequent clinical failure of aldose reductase inhibitors.[7]